105949 <common-name>Arbaclofen placarbil</common-name> <description>Arbaclofen placarbil is an organic compound with the formula C19H26ClNO6 and an average molecular weight of 399.87 g/mol. Arbaclofen placarbil belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. In terms of its pharmacological activity, the compound acts as an agonist for three recorded protein targets. These targets include the Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1), the Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2), and the Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3).</description> <cas>847353-30-4</cas> <pubchem-id>11281011</pubchem-id> <chemical-formula>C19H26ClNO6</chemical-formula> <weight>399.9</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-05T12:44:04Z</created-at> <updated-at type="dateTime">2026-08-20T03:59:20Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB08892</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CC(C)[C@H](OC(=O)NC[C@H](CC(O)=O)C1=CC=C(Cl)C=C1)OC(=O)C(C)C</moldb-smiles> <moldb-formula>C19H26ClNO6</moldb-formula> <moldb-inchi>InChI=1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1</moldb-inchi> <moldb-inchikey>JXTAALBWJQJLGN-KSSFIOAISA-N</moldb-inchikey> <moldb-average-mass type="decimal">399.87</moldb-average-mass> <moldb-mono-mass type="decimal">399.1448652</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>4.37</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM101842</chemdb-id> <dsstox-id>DTXSID40233754</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00071057</susdat-id> <iupac>(3R)-3-(4-chlorophenyl)-4-({[(1S)-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl}amino)butanoic acid</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organic acids and derivatives</superklass> <klass>Carboxylic acids and derivatives</klass> <subklass>Amino acids, peptides, and analogues</subklass> <paper-count type="integer">58</paper-count> <sync-id>CED0022458</sync-id> <structure-inchikey>JXTAALBWJQJLGN-KSSFIOAISA-N</structure-inchikey> 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