81499 <common-name>Loteprednol</common-name> <description>Loteprednol is an organic compound with the formula C21H27Cl1O5 and an average molecular weight of 394.89 g/mol. Loteprednol belongs to the androstane steroids, a subclass of steroids and steroid derivatives within the organic compounds. It acts as an agonist of the Glucocorticoid receptor (NR3C1). This substance has been found in or released from household cleaning and consumer products, specifically other smoking requisites.</description> <cas>129260-79-3</cas> <pubchem-id>9865442</pubchem-id> <chemical-formula>C21H27Cl1O5</chemical-formula> <weight>394.9</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-04T18:14:31Z</created-at> <updated-at type="dateTime">2026-08-21T19:28:03Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB00873</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)OCCl</moldb-smiles> <moldb-formula>C21H27Cl1O5</moldb-formula> <moldb-inchi>InChI=1S/C21H27ClO5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,18(25)27-11-22)20(15,2)10-16(24)17(14)19/h5,7,9,14-17,24,26H,3-4,6,8,10-11H2,1-2H3</moldb-inchi> <moldb-inchikey>YPZVAYHNBBHPTO-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">394.89</moldb-average-mass> <moldb-mono-mass type="decimal">394.154702</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.52</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id>392049</chemspider-id> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM077392</chemdb-id> <dsstox-id>DTXSID10156128</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00040707</susdat-id> <iupac>chloromethyl 11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Lipids and lipid-like molecules</superklass> <klass>Steroids and steroid derivatives</klass> <subklass>Androstane steroids</subklass> <paper-count type="integer">1502</paper-count> <sync-id>CED0007330</sync-id> <structure-inchikey>YPZVAYHNBBHPTO-MXRBDKCISA-N</structure-inchikey> 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<structure-indexed-at type="dateTime">2026-09-19T04:28:07Z</structure-indexed-at> </compound>