61281 <common-name>Picropodophyllin</common-name> <description>Picropodophyllin is an organic compound with the formula C22H22O8 and an average molecular weight of 414.41 g/mol. Picropodophyllin belongs to the podophyllotoxins, a subclass of lignan lactones within the organic compounds. The compound is found in or released from 13 recorded sources across multiple sectors. These include electrical and electronic equipment, such as cell phones, capacitors, wires and cables, batteries, and printed circuit boards. It is also present in textiles, leather and furnishings, specifically synthetic textiles, carpets and rugs, as well as food packaging within the food, food processing and cookware sector. Additionally, it is associated with medical devices in healthcare, pharmaceuticals and veterinary products, and lubricants used in energy, oil and gas, as well as industrial manufacturing and chemical processing. Other sectors also contribute to its presence. Recorded exposure routes for the compound include inhalation, oral, and touch. Regarding its biological activity, picropodophyllin acts as an inhibitor of the insulin-like growth factor 1 receptor (IGF1R).</description> <cas>477-47-4;17434-18-3</cas> <pubchem-id>72435</pubchem-id> <chemical-formula>C22H22O8</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-03-31T17:29:45Z</created-at> <updated-at type="dateTime">2026-04-14T19:04:51Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB12802</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>[H][C@]12COC(=O)[C@@]1([H])[C@H](C1=CC(OC)=C(OC)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@@H]2O</moldb-smiles> <moldb-formula>C22H22O8</moldb-formula> <moldb-inchi>InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1</moldb-inchi> <moldb-inchikey>YJGVMLPVUAXIQN-HAEOHBJNSA-N</moldb-inchikey> <moldb-average-mass type="decimal">414.41</moldb-average-mass> <moldb-mono-mass type="decimal">414.131468</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp nil="true"/> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id>65362</chemspider-id> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM057174</chemdb-id> <dsstox-id>DTXSID80197245</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00009071</susdat-id> <iupac>(5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Lignans, neolignans and related compounds</superklass> <klass>Lignan lactones</klass> <subklass>Podophyllotoxins</subklass> <paper-count type="integer">746</paper-count> <sync-id>CED0009589</sync-id> <structure-inchikey>YJGVMLPVUAXIQN-HAEOHBJNSA-N</structure-inchikey> 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����������������������������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:14:41Z</structure-indexed-at> </compound>