23234 <common-name>Lercanidipine</common-name> <description>Lercanidipine is an organic compound with the formula C36H41N3O6. Lercanidipine belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. With an average molecular weight of 611.73 g/mol, Lercanidipine is a heavy molecule. It acts as a blocker or inhibitor of two recorded protein targets: the Voltage-dependent calcium channel gamma-1 subunit (CACNG1) and the Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1).</description> <cas>100427-26-7</cas> <pubchem-id>65866</pubchem-id> <chemical-formula>C36H41N3O6</chemical-formula> <weight>611.7</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2016-05-25T18:21:03Z</created-at> <updated-at type="dateTime">2026-08-22T11:54:22Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB00528</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=C1</moldb-smiles> <moldb-formula>C36H41N3O6</moldb-formula> <moldb-inchi>InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3</moldb-inchi> <moldb-inchikey>ZDXUKAKRHYTAKV-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">611.7272</moldb-average-mass> <moldb-mono-mass type="decimal">611.299536059</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>6.41</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id>59276</chemspider-id> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM022129</chemdb-id> <dsstox-id>DTXSID2048327</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00002039</susdat-id> <iupac>3-{1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate</iupac> <moldb-polar-surface-area>113.69</moldb-polar-surface-area> <moldb-refractivity>177.8529999999999</moldb-refractivity> <moldb-polarizability>65.78264561142419</moldb-polarizability> <moldb-rotatable-bond-count>14</moldb-rotatable-bond-count> <moldb-acceptor-count>6</moldb-acceptor-count> <moldb-donor-count>1</moldb-donor-count> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic>9.36311699921927</moldb-pka-strongest-basic> <moldb-physiological-charge>1</moldb-physiological-charge> <moldb-number-of-rings>4</moldb-number-of-rings> <moldb-alogps-logp>6.42</moldb-alogps-logp> <moldb-alogps-logs>-6.59</moldb-alogps-logs> <moldb-alogps-solubility>1.56e-04 g/l</moldb-alogps-solubility> <kingdom>Organic compounds</kingdom> <superklass>Benzenoids</superklass> <klass>Benzene and substituted derivatives</klass> <subklass>Diphenylmethanes</subklass> <paper-count type="integer">396</paper-count> <sync-id>CED0007453</sync-id> <structure-inchikey>ZDXUKAKRHYTAKV-UHFFFAOYSA-N</structure-inchikey> 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