21156 <common-name>Amineptine</common-name> <description>Amineptine is an organic compound with the chemical formula C22H27NO2 and an average molecular weight of 337.46 g/mol. Amineptine belongs to the dibenzocycloheptenes, a class of benzenoids within the organic compounds. Regarding its pharmacological activity, the compound acts on three recorded protein targets. It functions as an inhibitor of the sodium-dependent dopamine transporter (SLC6A3), the sodium-dependent noradrenaline transporter (SLC6A2), and the sodium-dependent serotonin transporter (SLC6A4).</description> <cas>57574-09-1</cas> <pubchem-id nil="true"/> <chemical-formula>C22H27NO2</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2016-05-22T06:44:22Z</created-at> <updated-at type="dateTime">2026-05-14T18:10:48Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB04836</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>OC(=O)CCCCCCNC1C2=CC=CC=C2CCC2=CC=CC=C12</moldb-smiles> <moldb-formula>C22H27NO2</moldb-formula> <moldb-inchi>InChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)</moldb-inchi> <moldb-inchikey>ONNOFKFOZAJDHT-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">337.463</moldb-average-mass> <moldb-mono-mass type="decimal">337.204179113</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.74</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id>32091</chemspider-id> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM020051</chemdb-id> <dsstox-id>DTXSID1048831</dsstox-id> <toxcast-id>48831</toxcast-id> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00015371</susdat-id> <iupac>7-({tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}amino)heptanoic acid</iupac> <moldb-polar-surface-area>49.33</moldb-polar-surface-area> <moldb-refractivity>101.21099999999997</moldb-refractivity> <moldb-polarizability>39.71536855059136</moldb-polarizability> <moldb-rotatable-bond-count>8</moldb-rotatable-bond-count> <moldb-acceptor-count>3</moldb-acceptor-count> <moldb-donor-count>2</moldb-donor-count> <moldb-pka-strongest-acidic>4.413066575668882</moldb-pka-strongest-acidic> <moldb-pka-strongest-basic>9.173827850307374</moldb-pka-strongest-basic> <moldb-physiological-charge>0</moldb-physiological-charge> <moldb-number-of-rings>3</moldb-number-of-rings> <moldb-alogps-logp>1.99</moldb-alogps-logp> <moldb-alogps-logs>-6.04</moldb-alogps-logs> <moldb-alogps-solubility>3.05e-04 g/l</moldb-alogps-solubility> <kingdom>Organic compounds</kingdom> <superklass>Benzenoids</superklass> <klass>Dibenzocycloheptenes</klass> <subklass nil="true"/> <paper-count type="integer">317</paper-count> <sync-id>CED0013043</sync-id> <structure-inchikey>ONNOFKFOZAJDHT-UHFFFAOYSA-N</structure-inchikey> 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<structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ������������������������€���h��������(�������(�������`�������`�������`�������`�������`�������`�������`�������`������@(������@h�������@h�������@h�������@h�������@(�������`�������`������@(������@h�������@h�������@h�������@h�������@(�������� ��(�������������������� � � ����h�� h� �h���h���h������������h���h���h���h���h�� ���h���h�B����� �������� ���������������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:08:24Z</structure-indexed-at> </compound>