4806
T3D4751
Dihydrotestosterone
Dihydrotestosterone is a potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. -- Pubchem; Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. DHT is thought to be approximately 30 times more potent than testosterone because of increased affinity to the androgen receptor. -- Wikipedia.
521-18-6
10635
C19H30O2
White powder.
181°C
525 mg/mL at 25°C
Bioavailability is very low (0-2%) following oral administration.
No indication of carcinogenicity to humans (not listed by IARC).
Dihydrotestosterone is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.
2014-09-11T05:14:48Z
2016-11-09T01:09:12Z
http://en.wikipedia.org/wiki/Dihydrotestosterone
C03917
16330
17-BETA-HYDROXY-5ALPHA-ANDROSTAN-3-O
DB02901
DHT
true
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C
C19H30O2
InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
NVKAWKQGWWIWPM-ABEVXSGRSA-N
290.4403
290.224580204
Endogenous
Solid
3.55
HMDB02961
14
<p>A. Glenn Braswell, Aftab J. Ahmed, “Composition for inhibiting production of dihydrotestosterone to treat benign prostate hyperplasia.” U.S. Patent US6264996, issued October, 1996.</p>
CHEM003708