4799 Diethylstilbestrol A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. 56-53-1 448537 C18H20O2 White powder. 172°C 12 mg/L (at 25°C) Estrogens diffuse into their target cells and interact with a protein receptor, the estrogen receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. The effect of Estrogen binding their receptors causes downstream increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Hepatic. 1, carcinogenic to humans. (L135) Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. 2014-09-11T05:14:27Z 2026-03-31T19:50:24Z Diethylstilbestrol C07620 4531 DB00255 DES true CC\C(=C(\CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1 C18H20O2 InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ RGLYKWWBQGJZGM-ISLYRVAYSA-N 268.356 268.146329884 Exogenous Solid 5.07 HMDB14400 CHEMBL411 2946 <p>Adler, E.,Gie, G.J. and von Euler, H.; US. Patent 2,421,401; June 3, 1947; assigned to Hoffmann-La Roche, Inc.</p> CHEM003701 DTXSID3020465 NS00010902 4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol