4789 T3D4734 Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. 89365-50-4 5152 C25H37NO4 White powder. 75.5-76.5°C Sparingly soluble Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses. Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the molecule to remain at the receptor site, continually binding and releasing. Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow. Hepatic, metabolized by hydroxylation via CYP3A4 Half Life: 5.5 hours By the oral route, no deaths occurred in rats at 1,000 mg/kg (approximately 81,000 times the maximum recommended daily inhalation dose in adults and approximately 38,000 times the maximum recommended daily inhalation dose in children on a mg/m<sup>2</sup> basis). No indication of carcinogenicity to humans (not listed by IARC). For the treatment of asthma and chronic obstructive pulmonary disease (COPD). Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor. 2014-09-11T05:13:58Z 2026-03-31T19:02:27Z Salmeterol C07241 DB00938 true OCC1=C(O)C=CC(=C1)C(O)CNCCCCCCOCCCCC1=CC=CC=C1 C25H37NO4 InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2 GIIZNNXWQWCKIB-UHFFFAOYSA-N 415.5656 415.272258677 Exogenous Solid 4.2 CHEMBL1263 4968 <p>Panayiotis Procopiou, &#8220;Novel process for preparing salmeterol.&#8221; U.S. Patent US20030162840, issued August 28, 2003.</p> CHEM003691 DTXSID6023571 NS00010340 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol