4767 Propylthiouracil Propylthiouracil is only found in individuals that have used or taken this drug. It is a thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones. 51-52-5 657298 C7H10N2OS White powder. 219°C 1200 mg/L (at 25°C) Well absorbed following oral administration. Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones. Route of Elimination: Propylthiouracil is readily absorbed and is extensively metabolized. Approximately 35% of the drug is excreted in the urine, in intact and conjugated forms, within 24 hours. Half Life: 2 hours Oral, rat: LD₅₀ = 1250 mg/kg. 2B, possibly carcinogenic to humans. (L135) Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease). 2014-09-11T02:06:03Z 2026-05-14T16:41:58Z http://en.wikipedia.org/wiki/Propylthiouracil C07569 8502 DB00550 true CCCC1=CC(=O)NC(=S)N1 C7H10N2OS InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11) KNAHARQHSZJURB-UHFFFAOYSA-N 170.232 170.051383642 Exogenous Solid 0.4 HMDB14690 CHEMBL1518 571424 CHEM003670 DTXSID5021209 6-propyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one 41.13 48.90429999999999 17.793220385184945 2 1 2 8.089442965478288 -2.9166377722651 0 1 1.53 -2.56 4.66e-01 g/l