4756 Medroxyprogesterone Medroxyprogesterone is a synthetic progesterone (steroid hormone) involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. Progesterone's reproductive function serves to convert the endometrium to its secretory stage to prepare the uterus for implantation. If pregnancy does not occur, progesterone levels will decrease leading to menstruation in the human. Normal menstrual bleeding is a progesterone withdrawal bleeding. During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. Progesterone decreases contractility of the uterine musculature. The fetus metabolizes placental progesterone in the production of adrenal mineralo and glucosteroids. A drop in progesterone levels is possibly one step that facilitates the onset of labor. In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone has an effect upon vaginal epithelium and cervical mucus. A synthetic progestational hormone used in veterinary practice as an estrus regulator. 520-85-4 10631 C22H32O3 White powder. 214.5 °C No indication of carcinogenicity to humans (not listed by IARC). 2014-09-11T02:05:35Z 2026-04-13T20:33:53Z http://en.wikipedia.org/wiki/Medroxyprogesterone C07119 6715 DB00603 true [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C C22H32O3 InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1 FRQMUZJSZHZSGN-HBNHAYAOSA-N 344.4877 344.23514489 Exogenous Solid HMDB01939 CHEMBL1390 10185 CHEM003659 DTXSID0036508 NS00009207 54.37 98.65389999999998 40.073591801354276 1 3 1 12.699646357350076 -3.804965370680798 0 4 3.52 -4.35 1.54e-02 g/l