4739 Chlorambucil A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). 305-03-3 2708 C14H19Cl2NO2 White powder. 65°C 1.24E+004 mg/L Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Route of Elimination: Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard. The pharmacokinetic data suggests that oral chlorambucil undergoes rapid gastrointestinal absorption and plasma clearance and that it is almost completely metabolized, having extremely low urinary excretion. Half Life: 1.5 hours 1, carcinogenic to humans. (L135) For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenstrн_mду»s Macroglobulinemia. 2014-09-11T02:04:51Z 2026-03-31T18:14:19Z http://en.wikipedia.org/wiki/Chlorambucil C06900 28830 DB00291 CBL true OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl C14H19Cl2NO2 InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) JCKYGMPEJWAADB-UHFFFAOYSA-N 304.212 303.079284271 Exogenous Solid 1.7 HMDB14436 CHEMBL515 2607 <p>Phillips, A. P. and Mentha, J.W.; U.S.Patent 3,046,301; July 24, 1962; assigned to Burroughs<br /> Wellcome &amp; Co. (U.S.A.) Inc.</p> CHEM003642 DTXSID7020263 NS00009960 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid