4460 O-Phosphoethanolamine Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. PE is a precursor of phospholipid synthesis and a product of phospholipid breakdown. Phosphomonoesters are present at much higher levels in brain than in other organs. In developing brain, phosphomonoesters are normally elevated during the period of neuritic proliferation. This also coincides with the occurrence of normal programmed cell death and synaptic pruning in developing brain. These findings are consistent with the role of phosphomonoesters in membrane biosynthesis. PE shows a strong structural similarity to the inhibitory neurotransmitter, GABA, and the GABAB receptor partial agonist, 3-amino-propylphosphonic acid. PE is a phosphomonoester which is decreased in post-mortem Alzheimer's disease (AD) brain. (A3481, A3482, A3483). 1071-23-4 1015 C2H8NO4P White powder. 241 - 243°C 72 mg/mL No indication of carcinogenicity to humans (not listed by IARC). This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation. 2014-08-29T06:51:02Z 2026-05-14T17:14:42Z Phosphoethanolamine C00346 17553 PHOSPHORYL-ETHANOLAMINE DB01738 OPE true NCCOP(O)(O)=O C2H8NO4P InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6) SUHOOTKUPISOBE-UHFFFAOYSA-N 141.063 141.019094261 Endogenous Solid -2.5 HMDB00224 CHEMBL146972 990 CHEM003366 DTXSID5061453 (2-aminoethoxy)phosphonic acid 92.77999999999999 27.084 11.11675089618825 3 4 3 1.5391795005429323 10.017192603268537 -1 0 -1.54 -0.74 2.58e+01 g/l