4412 Glutaconic acid Glutaconic acid is an organic compound with general formula C5H6O4. The compound is a dicarboxylic acid and related with the fully saturated glutaric acid. 1724-02-3 5280498 C5H6O4 White powder. 133 - 135°C Accumulating trans-glutaconic (TG) acids has been proposed to be involved in the development of the striatal degeneration seen in children with glutaric acidemia type 1 (GA1) via an excitotoxic mechanism. TG is neurotoxic and neurotoxicity is thought to be caused by an excitotoxic mechanism in which TG overactivates N-methyl-D-aspartate (NMDA) receptors. (A15451) In glutaric aciduria type 1, glutaconic acid accumulates, resulting in brain damage. (Wikipedia) No indication of carcinogenicity to humans (not listed by IARC). This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation. Chronically high levels of glutaconic acid are associated with Glutaric Aciduria Type I. 2014-08-29T06:33:58Z 2026-04-03T00:50:57Z Glutaconic acid C02214 15670 GLUTACONATE true OC(=O)C\C=C\C(O)=O C5H6O4 InChI=1S/C5H6O4/c6-4(7)2-1-3-5(8)9/h1-2H,3H2,(H,6,7)(H,8,9)/b2-1+ XVOUMQNXTGKGMA-OWOJBTEDSA-N 130.0987 130.02660868 Endogenous Solid HMDB00620 CHEMBL557347 4444138 Schwarz, Siegfried; Bohn, Helmut; Schmidt, Dieter; Kulpa, Manfred; Spakowski, Horst; Becker, Manfred. Glutaconic acid. Ger. (East) (1967), 2 pp. CHEM003318 DTXSID70211883 74.6 29.231299999999997 11.364693301928234 3 4 2 3.6919558338662966 -2 0 0.05 -0.87 1.76e+01 g/l