4376 T3D4322 Uroporphyrin III Uroporphyrin is the porphyrin produced by oxidation of the methylene bridges in uroporphyrinogen. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation. Excessive amounts of uroporphyrin I are excreted in congenital erythropoietic porphyria, and both types I and III are excreted in porphyria cutanea tarda. Uroporphyrin I and III are the most common isomers. 18273-06-8 C40H38N4O16 White powder. No indication of carcinogenicity to humans (not listed by IARC). This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation. Chronically high levels of porophyrins are associated with porphyrias such as Porphyria variegate, Acute Intermittent Porphyria and Hereditary Coproporphyria (HCP). 2014-08-29T06:25:21Z 2026-04-05T15:27:02Z C02469 15436 UROPORPHYRIN_III DB04461 UFE true OC(=O)CCC1=C(CC(O)=O)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(CC(O)=O)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(CC(O)=O)=C4CCC(O)=O)/C(CCC(O)=O)=C3CC(O)=O C40H38N4O16 InChI=1S/C40H38N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-27-19(3-7-35(49)50)22(10-38(55)56)30(43-27)15-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)16-31-23(11-39(57)58)18(2-6-34(47)48)26(42-31)13-25(17)41-29/h13-16,41,44H,1-12H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16- VZVFNUAIRVUCEW-UJJXFSCMSA-N 830.7469 830.228281188 Endogenous Solid HMDB00916 16736727 <p>Ichiro Kojima, Kenji Maruhashi, Yasuo Fujiwara, &#8220;Process for producing coproporphyrin <span class="caps">III</span>.&#8221; U.S. Patent US4334021, issued September, 1978.</p> CHEM003282 DTXSID70896977 NS00075509 355.76 201.32140000000018 85.11525153387961 20 18 10 3.108325482263556 -8 5 0.79 -4.35 3.75e-02 g/l