4366 Carnosine Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. It is a dipeptide of the amino acids beta-alanine and histidine. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the hyperactivity seen in autistic subjects at higher doses. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability (A3405, A3406). 305-84-0 439224 C9H14N4O3 White powder. 253 - 256°C 384 mg/mL No indication of carcinogenicity to humans (not listed by IARC). This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation. 2014-08-29T06:19:04Z 2026-05-14T19:11:45Z Carnosine C00386 15727 CARNOSINE DB11695 true NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O C9H14N4O3 InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 226.2325 226.106590334 Endogenous Solid -4.5 HMDB00033 CHEMBL242948 388363 Vezenkov, L.; Yanachkov, O. Synthesis of carnosine by trimethylsilyl protection. Dokladi na Bulgarskata Akademiya na Naukite (1991), 44(8), 53-6 CHEM003272 (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid 121.1 55.56190000000001 22.36612322974625 6 5 4 3.371243802200665 9.12598191586239 1 1 -2.96 -1.31 1.11e+01 g/l