4354 T3D4300 Dopamine One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem] 51-61-6 681 C8H11NO2 White powder. 128°C 227°C at 2.30E+01 mm Hg 600 g/L Dopamine is rapidly absorbed from the small intestine. Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, dopamine actas as an agonist to the five dopamine receptor subtypes (D!, D2, D3, D4, D5). Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA). Route of Elimination: It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged. Half Life: 2 minutes LD<sub>50</sub> oral mice = 1460 mg/kg, LD<sub>50</sub> oral rats = 1780 mg/kg No indication of carcinogenicity to humans (not listed by IARC). For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure Chronically high levels of dopamine are associated with at least 2 inborn errors of metabolism including: Aromatic L-Amino acid Decarboxylase Deficiency and Norepinephrine deficiency. 2014-08-29T06:17:08Z 2026-05-14T16:55:05Z Dopamine C03758 18243 DOPAMINE DB00988 LDP true NCCC1=CC(O)=C(O)C=C1 C8H11NO2 InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 VYFYYTLLBUKUHU-UHFFFAOYSA-N 153.1784 153.078978601 Endogenous Solid -0.98 HMDB00073 CHEMBL59 661 <p>Klaus Schoellkopf, Rudolf Albrecht, Manfred Lehmann, Gertrud Schroeder, &#8220;Novel dopamine derivatives, processes for their preparation, and their use as medicinal agents.&#8221; U.S. Patent US4958026, issued February, 1972.</p> CHEM003260 DTXSID6022420 NS00000608 4-(2-aminoethyl)benzene-1,2-diol 66.48 43.248200000000004 16.210926868007363 2 3 3 10.007776384659529 9.271456202535882 1 1 -0.40 -1.31 7.43e+00 g/l