<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">4339</id>
  <title>T3D4285</title>
  <common-name>Corticosterone</common-name>
  <description>Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).</description>
  <cas>50-22-6</cas>
  <pubchem-id>5753</pubchem-id>
  <chemical-formula>C21H30O4</chemical-formula>
  <weight>346.5</weight>
  <appearance>White powder.</appearance>
  <melting-point>179°C</melting-point>
  <boiling-point></boiling-point>
  <density nil="true"/>
  <solubility>0.199 mg/mL</solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure nil="true"/>
  <target nil="true"/>
  <mechanism-of-toxicity nil="true"/>
  <metabolism nil="true"/>
  <toxicity nil="true"/>
  <lethaldose nil="true"/>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.</use-source>
  <min-risk-level nil="true"/>
  <health-effects nil="true"/>
  <symptoms nil="true"/>
  <treatment nil="true"/>
  <created-at type="dateTime">2014-08-29T06:15:15Z</created-at>
  <updated-at type="dateTime">2026-05-14T18:09:37Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia>Corticosterone</wikipedia>
  <uniprot-id nil="true"/>
  <kegg-compound-id>C02140</kegg-compound-id>
  <omim-id nil="true"/>
  <chebi-id>16827</chebi-id>
  <biocyc-id nil="true"/>
  <ctd-id nil="true"/>
  <stitch-id nil="true"/>
  <drugbank-id>DB04652</drugbank-id>
  <pdb-id>C0R</pdb-id>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@]([H])(O)C[C@]12C)C(=O)CO</moldb-smiles>
  <moldb-formula>C21H30O4</moldb-formula>
  <moldb-inchi>InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1</moldb-inchi>
  <moldb-inchikey>OMFXVFTZEKFJBZ-HJTSIMOOSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">346.4605</moldb-average-mass>
  <moldb-mono-mass type="decimal">346.214409448</moldb-mono-mass>
  <origin>Endogenous</origin>
  <state>Solid</state>
  <logp>1.94</logp>
  <hmdb-id>HMDB01547</hmdb-id>
  <chembl-id>CHEMBL110739</chembl-id>
  <chemspider-id>5550</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM003245</chemdb-id>
  <dsstox-id>DTXSID6022474</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00000569</susdat-id>
  <iupac>(1S,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one</iupac>
  <moldb-polar-surface-area>74.6</moldb-polar-surface-area>
  <moldb-refractivity>95.99999999999997</moldb-refractivity>
  <moldb-polarizability>38.834714064835836</moldb-polarizability>
  <moldb-rotatable-bond-count>2</moldb-rotatable-bond-count>
  <moldb-acceptor-count>4</moldb-acceptor-count>
  <moldb-donor-count>2</moldb-donor-count>
  <moldb-pka-strongest-acidic>13.864721771653453</moldb-pka-strongest-acidic>
  <moldb-pka-strongest-basic>-0.25948436298940314</moldb-pka-strongest-basic>
  <moldb-physiological-charge>0</moldb-physiological-charge>
  <moldb-number-of-rings>4</moldb-number-of-rings>
  <moldb-alogps-logp>2.09</moldb-alogps-logp>
  <moldb-alogps-logs>-3.88</moldb-alogps-logs>
  <moldb-alogps-solubility>4.60e-02 g/l</moldb-alogps-solubility>
</compound>
