4289 Aplysiatoxin Aplysiatoxin is a cyanotoxin produced by certain cyanobacteria species. It is used as a defensive secretion to protect these cyanobacteria from predation by fish, being a potent irritant and carcinogen, by acting as a powerful activator of Protein kinase C. It has dermatotoxic activity causing inflamation of the skin. They are also potent tumour promoters. 52659-57-1 21672114 C32H47BrO10 White powder. Dermal; ingestion. Aplysiatoxin is a 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoter that activates protein kinase C (PKC) (A15358). In cancer cells, PKC isozymes are involved in cell proliferation, survival, invasion, migration, apoptosis, angiogenesis, and anticancer drug resistance through their increased or decreased participation in various cellular signaling pathways (L2138). Not listed by IARC. Aplysiatoxin is a cyanotoxin produced by certain cyanobacteria species. It is used as a defensive secretion to protect these cyanobacteria from predation by fish, being a potent irritant and carcinogen, by acting as a powerful activator of Protein kinase C. It has dermatotoxic activity causing inflamation of the skin. Aplysiatoxin is one of the causative agents of 'swimmer’s itch'. It also has tumor-promoting effects. Aplysiatoxin and debromoaplysiatoxin were found to be the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii (A15448). Inflammation of the skin. Vomiting, diarrhea and burning sensation of the mouth and throat (A15448). 2014-08-29T05:57:31Z 2026-04-05T15:32:55Z Aplysiatoxin C16769 true [H][C@](C)(O)[C@@]1([H])CC(=O)O[C@@]2([H])C[C@]3(O[C@]([H])([C@@]([H])(C)CC[C@]([H])(OC)C4=C(Br)C=CC(O)=C4)[C@@]2([H])C)O[C@@](O)(CC(=O)O1)[C@]([H])(C)CC3(C)C C32H47BrO10 InChI=1S/C32H47BrO10/c1-17(8-11-24(39-7)22-12-21(35)9-10-23(22)33)29-19(3)26-15-32(42-29)30(5,6)14-18(2)31(38,43-32)16-28(37)40-25(20(4)34)13-27(36)41-26/h9-10,12,17-20,24-26,29,34-35,38H,8,11,13-16H2,1-7H3/t17-,18+,19-,20+,24-,25+,26-,29+,31-,32-/m0/s1 RHJPBGWFGOAEID-BEDNPZBZSA-N 671.614 670.235260371 Exogenous Solid CHEMBL1256416 10282349 CHEM003195 DTXSID60880082 NS00075604 140.98 159.71330000000006 66.28279848842382 7 8 3 8.917008091749306 -3.0342786881768538 0 4 4.22 -4.99 6.86e-03 g/l