4188 Taxine B Taxine B is a cardiotoxic alkaloid found in Yew trees. It is significantly more toxic than its counterpart, taxine A, and has both negative inotropic and atrioventricular conduction delay effects. Taxine B induced AV conduction delay produces the classic increase in the electro-cardiographic QRS complex duration that is observed in people, pigs, and guinea pigs with yew toxicosis. The p wave may also be depressed or absent. Taxine B also acts as a class I antiarrhythmic drug and, thus, reduces cardiac contractility and the maximum rate of depolarization. (A3254). 1361-51-9 121443 C33H45NO8 White powder. No indication of carcinogenicity to humans (not listed by IARC). Taxine B is a cardiotoxic alkaloid found in Yew trees. 2014-08-29T05:30:05Z 2026-05-21T01:48:08Z C19989 true CN(C)C(CC(=O)OC1CCC2(C)C(C(O)C3(O)CC(=O)C(C)=C(C(OC(C)=O)C2O)C3(C)C)C1=C)C1=CC=CC=C1 C33H45NO8 InChI=1S/C33H45NO8/c1-18-23(36)17-33(40)29(38)27-19(2)24(42-25(37)16-22(34(7)8)21-12-10-9-11-13-21)14-15-32(27,6)30(39)28(41-20(3)35)26(18)31(33,4)5/h9-13,22,24,27-30,38-40H,2,14-17H2,1,3-8H3 XMZFIBDTPOUHMW-UHFFFAOYSA-N 583.7123 583.314517421 Exogenous Solid 108387 CHEM003094 DTXSID40276247 NS00094709 133.60000000000002 156.46240000000003 60.99854279140466 8 7 3 12.924286561487968 8.787897039525712 1 4 2.71 -4.17 3.92e-02 g/l