4169 Rhodexin A Rhodexin A is a toxic glycoside that is the rhamnoside of sarmentogenin. Found in the leaves and roots of the Japanese evergreen Rhodea japonica, it has also been found in several other plant species. Besides being the only compound in its family to display a digitalis-like action in the cat heart, rhodexin A is also active against human leukemia K562 cells. Indeed, it is one of a series of cardiac glycosides that have potent antiproliferative activity, which has been attributed to their ability to inhibit synthesis of hypoxia inducible factor 1 (HIF-1-alpha) (A3241, A3242). 545-49-3 441868 C29H44O9 White powder. No indication of carcinogenicity to humans (not listed by IARC). Found in the leaves and roots of the Japanese evergreen Rhodea japonica, it has also been found in several other plant species. 2014-08-29T05:17:53Z 2026-05-21T00:37:49Z C08877 true [H][C@@]1(CC[C@]2(O)[C@]3([H])CC[C@]4([H])C[C@]([H])(CC[C@]4(C)[C@@]3([H])[C@]([H])(O)C[C@]12C)O[C@]1([H])O[C@@]([H])(C)[C@]([H])(O)[C@@]([H])(O)[C@@]1([H])O)C1=CC(=O)OC1 C29H44O9 InChI=1S/C29H44O9/c1-14-23(32)24(33)25(34)26(37-14)38-17-6-8-27(2)16(11-17)4-5-19-22(27)20(30)12-28(3)18(7-9-29(19,28)35)15-10-21(31)36-13-15/h10,14,16-20,22-26,30,32-35H,4-9,11-13H2,1-3H3/t14-,16+,17-,18+,19+,20+,22+,23-,24+,25+,26-,27-,28+,29-/m0/s1 HFMLTKBZNAPPNY-CEKKCSHUSA-N 536.6543 536.298533006 Exogenous Solid 390444 CHEM003075 DTXSID301318334 NS00093822 145.91 136.10270000000003 58.15579198982565 3 8 5 7.181446972867483 -2.8443196870610494 0 6 0.62 -3.20 3.41e-01 g/l