4146 Dicentrine Dicentrine is an anticancer compound isolated from Lindera, a species of flowering plants. 517-66-8 101300 C20H21NO4 White powder. Dicentrine was found to be a potent alpha 1-adrenoceptor blocking agent in rat thoracic aorta as revealed by its competitive antagonism of noradrenaline- (pA2 = 8.19 +/- 0.09) or phenylephrine (pA2 = 9.01 +/- 0.10)-induced vasoconstriction. These effects still persisted in denuded aorta. Dicentrine inhibited platelet aggregation and release reaction through the suppression of thromboxane formation and elevation of adenosine 3': S'-cyclic monophosphate. (A15323) d-Dicentrine significantly inhibits the growth of human hepatoma cell line HuH-7 by delaying its doubling time in tissue culture. An in vitro colony forming assay showed that d-dicentrine decreased the colony formation efficiency in both hepatoma cell lines, HuH-7 and MS-G2. An MTT assay in 21 tumor cell lines also revealed that d-dicentrine was most cytotoxic to esophageal carcinoma HCE-6, lymphoma cell lines Molt-4 and CESS, leukemia cell lines HL60 and K562, and hepatoma cell line MS-G2. (A15341) Dicentrine is also a selective α1-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities. (A15324) No indication of carcinogenicity to humans (not listed by IARC). Dicentrine is an anticancer compound isolated from Lindera, a species of flowering plants. 2014-08-29T05:07:05Z 2026-04-06T02:08:15Z C17426 true [H][C@]12CC3=CC(OC)=C(OC)C=C3C3=C1C(CCN2C)=CC1=C3OCO1 C20H21NO4 InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1 YJWBWQWUHVXPNC-AWEZNQCLSA-N 339.385 339.147058165 Exogenous Solid CHEMBL464748 91532 CHEM003052 DTXSID10199651 NS00094624 40.160000000000004 94.71959999999999 37.116456100708916 2 5 0 7.062561297435805 1 5 2.76 -3.63 8.05e-02 g/l