4128 Coriamyrtin The leaves and fruits of Coriaria myrtifolia contain coriamyrtin, a typical convulsant substance. 2571-86-0 442189 C15H18O5 White powder. Coriamyrtin has inhibitory activity when modulating receptors of the central nervous system. In other words, coriamyrtin, as a picrotoxin-like sesquiterpene lactones found in Anamirta paniculata and A. cocculus, has a mode of anticonvulsive action as potent transmission inhibitors in the central nervous system. The presence of a hydroxyl group at C-6 could have a significant affinity for a γ-aminobutyric acid (GABA) effector chloride channel, an antagonist to the effects observed on γ-aminobutyric acid but not on alanine or taurine. These experiments were tested on primary afferent terminals and for the antagonism of presynaptic inhibition. Picrotoxin is a known antagonist of GABA-R in all its protein isoforms and R-Gly in the homomeric form. (A15430) No indication of carcinogenicity to humans (not listed by IARC). 2014-08-29T05:03:08Z 2026-04-06T10:41:10Z Coriaria myrtifolia C09379 true [H][C@@]12O[C@]1([H])[C@@]1(O)[C@@]3([H])C(=O)O[C@@]([H])(C[C@@]1(C)[C@@]21CO1)[C@@]3([H])C(C)=C C15H18O5 InChI=1S/C15H18O5/c1-6(2)8-7-4-13(3)14(5-18-14)10-11(20-10)15(13,17)9(8)12(16)19-7/h7-11,17H,1,4-5H2,2-3H3/t7-,8+,9+,10+,11-,13-,14+,15-/m0/s1 BWWDLKVKPVKBGJ-TWMZOSGRSA-N 278.3004 278.115423686 Exogenous Solid 10252019 CHEM003034 NS00120562 (1'S,2R,2'R,3'S,5'R,7'R,9'S,12'R)-2'-hydroxy-7'-methyl-12'-(prop-1-en-2-yl)-4',10'-dioxaspiro[oxirane-2,6'-tetracyclo[7.2.1.0²,⁷.0³,⁵]dodecane]-11'-one