4117 Ranunculin Ranunculin is an instable glucoside found in plants of the buttercup family (Ranunculaceae). On maceration, for example when the plant is wounded, it is enzymatically broken down into glucose and the toxin protoanemonin. 644-69-9 441581 C11H16O8 White powder. 141-142°C Ranunculin (RAN) inhibited the incorporation of 3H-labeled precursors into DNA and RNA of L1210 cells. RAN (15 mumol/L) markedly decreased DNA synthesis catalyzed by DNA polymerase I and promoted the generation of superoxide anions in DMSO/KO2 system. In the meantime, SOD and CAT were shown to partly revoke the inhibitory effects of RAN upon the incorporation of 3H-TdR into DNA. The cytotoxicity of RAN in vitro may be due to inhibition of DNA polymerase and increase of oxygen free radicals. (A15425) No indication of carcinogenicity to humans (not listed by IARC). Ranunculin is an instable glucoside found in plants of the buttercup family (Ranunculaceae). On maceration, for example when the plant is wounded, it is enzymatically broken down into glucose and the toxin protoanemonin. 2014-08-29T05:00:33Z 2026-04-04T19:00:11Z Ranunculin C08512 true [H][C@]1(CO[C@]2([H])O[C@]([H])(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]2([H])O)OC(=O)C=C1 C11H16O8 InChI=1S/C11H16O8/c12-3-6-8(14)9(15)10(16)11(19-6)17-4-5-1-2-7(13)18-5/h1-2,5-6,8-12,14-16H,3-4H2/t5-,6+,8+,9-,10+,11+/m0/s1 TYWXNGXVSZRXNA-NVZSGMJQSA-N 276.2399 276.084517488 Exogenous Solid 390250 CHEM003023 DTXSID40982977 (5S)-5-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)-2,5-dihydrofuran-2-one