4093 Gonyautoxin II Gonyautoxin II is a neurotoxin that is a sodium channel blocker. 60508-89-6 11593018 C10H17N7O8S White powder. The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of Na+ ions and preventing nerve and muscle cells from producing action potentials, therefore, blocking neuronal transmission, which results in a temporary paralysis of muscles. Gonyautoxin paralyzes the injected sphincter reducing anal tone, leaving the other muscles unaffected. The paretic effect lasts for more than one week. Its effect is dose-dependent and the binding to its receptor site is only regulated by affinity.(A3261) No indication of carcinogenicity to humans (not listed by IARC). Gonyautoxin II is a neurotoxin that is a sodium channel blocker. 2014-08-29T04:54:37Z 2026-04-15T16:34:56Z C16856 DB19186 true NC(=O)OCC1NC(=N)N2CC(OS(O)(=O)=O)C(O)(O)C22NC(=N)NC12 C10H17N7O8S InChI=1S/C10H17N7O8S/c11-6-15-5-3(2-24-8(13)18)14-7(12)17-1-4(25-26(21,22)23)10(19,20)9(5,17)16-6/h3-5,19-20H,1-2H2,(H2,12,14)(H2,13,18)(H3,11,15,16)(H,21,22,23) ARSXTTJGWGCRRR-UHFFFAOYSA-N 395.349 395.085931245 Exogenous Solid HMDB33507 9767779 CHEM002999 DTXSID90880095 NS00004724 {4-[(carbamoyloxy)methyl]-10,10-dihydroxy-2,6-diimino-decahydropyrrolo[1,2-c]purin-9-yl}oxidanesulfonic acid