4092 Gonyautoxin I Gonyautoxin I is found in mollusks. Gonyautoxin I is produced by Gonyaulax and Protogonyaulax species and isolated from shellfish. It is a neurotoxin and the causal agent, with Saxitoxin, of shellfish poisoning. 60748-39-2 46173840 C10H17N7O9S White powder. The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of Na+ ions and preventing nerve and muscle cells from producing action potentials, therefore, blocking neuronal transmission, which results in a temporary paralysis of muscles. Gonyautoxin paralyzes the injected sphincter reducing anal tone, leaving the other muscles unaffected. The paretic effect lasts for more than one week. Its effect is dose-dependent and the binding to its receptor site is only regulated by affinity.(A3261) No indication of carcinogenicity to humans (not listed by IARC). 2014-08-29T04:54:13Z 2026-03-31T17:06:24Z C16855 true NC(=O)OCC1C2NC(=N)NC22N(CC(OS(O)(=O)=O)C2(O)O)C(=N)N1O C10H17N7O9S InChI=1S/C10H17N7O9S/c11-6-14-5-3(2-25-8(13)18)17(21)7(12)16-1-4(26-27(22,23)24)10(19,20)9(5,16)15-6/h3-5,12,19-21H,1-2H2,(H2,13,18)(H3,11,14,15)(H,22,23,24) CETRDCWBMBILAL-UHFFFAOYSA-N 411.348 411.080845867 Exogenous Solid HMDB33506 30791735 CHEM002998 DTXSID30880094 NS00008693 {4-[(carbamoyloxy)methyl]-5,10,10-trihydroxy-2,6-diimino-decahydropyrrolo[1,2-c]purin-9-yl}oxidanesulfonic acid