4077 Neosaxitoxin Neosaxitoxin is produced by Protogonyaulax and found in shellfish. Neosaxitoxin has been shown to exhibit anesthetic function. Neosaxitoxin belongs to the family of Saxitoxins, Gonyautoxins, and Derivatives. These are compounds whose structure is based on a 2,6-diamino-4-methyl-pyrrolo[1,2-c]purin-10-ol skeleton. (A3210). 64296-20-4 104753 C10H17N7O5 White powder. Neosaxitoxin (NSTX) blocks the extracellular portion, the outer vestibule, of some voltage gated sodium channels in a very powerful and reversible manner, without affection of other ion channels. NSTX and other site 1 blockers (i.e., tetrodotoxin and saxitoxin) have high affinity (very low dissociation constant) and high specificity for Nav channels ("Voltage gated", also called "voltage sensitive" and "voltage dependant" sodium channel also known as "VGSCs" or "Nav channel"). The action of NSTX produces minimal effect on cardiac Nav, where it exhibits about 20_60 fold lesser affinity than in Nav channels from rat skeletal muscle and rat brain. Toxins such as neosaxitoxin and tetrodotoxin have less affinity for most cardiac Nav channels than for most Nav channels in nerve tissue. Moreover, NSTX is so active on nerve Nav channel than is roughly a million-fold more potent than lidocaine. (Wikipedia) No indication of carcinogenicity to humans (not listed by IARC). 2014-08-29T04:49:22Z 2026-03-31T17:28:00Z C17208 true NC(=O)OC[C@H]1[C@@H]2NC(N)=N[C@]22N(CCC2(O)O)C(=N)N1O C10H17N7O5 InChI=1S/C10H17N7O5/c11-6-14-5-4(3-22-8(13)18)17(21)7(12)16-2-1-9(19,20)10(5,16)15-6/h4-5,12,19-21H,1-3H2,(H2,13,18)(H3,11,14,15)/t4-,5-,10-/m0/s1 PPEKGEBBBBNZKS-HGRQIUPRSA-N 315.2859 315.129116689 Exogenous Solid HMDB29369 19975931 CHEM002983 DTXSID70880098 NS00009030 [(4R,10aS,10bS)-2-amino-5,10,10-trihydroxy-6-imino-3H,4H,5H,6H,8H,9H,10H,10bH-pyrrolo[1,2-c]purin-4-yl]methyl carbamate