4021 Enterolactone Enterolactone is a mammalian lignan that have a similar biphenolic structure to lignans from plants. Lignans are compounds with estrogenic properties and are probably the most important source of phytoestrogens in western diets. Mammalian lignans are formed from precursors that are contained mainly in vegetables, whole grain products and berries, via action of intestinal microflora. Enterolactone is produced in the colon by the action of bacteria on secoisolariciresinol, matairesinol and its glycosides. Secoisolariciresinol is converted to enterodiol which is subsequently converted to enterolactone as it passes through the colon. Matairesinol is converted directly to enterolactone. Enterolactone have been shown to possess weakly estrogenic and antiestrogenic activities, and it has been suggested that the high production of this antiestrogenic mammalian lignans in the gut may serve to protect against breast cancer in women and prostate cancer in men; however epidemiological evidence to date is conflicting. (A3195, A3194, A3196, A3197). 76543-15-2 123917 C18H18O4 White powder. No indication of carcinogenicity to humans (not listed by IARC). Enterolactone is produced in the colon by the action of bacteria on secoisolariciresinol, matairesinol and its glycosides. 2014-08-29T04:48:01Z 2026-04-05T16:32:49Z 562788 2-CHLORO-TRANS-DIENELACTONE true OC1=CC=CC(CC2COC(=O)C2CC2=CC(O)=CC=C2)=C1 C18H18O4 InChI=1S/C18H18O4/c19-15-5-1-3-12(8-15)7-14-11-22-18(21)17(14)10-13-4-2-6-16(20)9-13/h1-6,8-9,14,17,19-20H,7,10-11H2 HVDGDHBAMCBBLR-UHFFFAOYSA-N 298.3331 298.120509064 Exogenous Solid HMDB06101 CHEMBL465152 110448 CHEM002927 DTXSID0048183 NS00076969 3,4-bis[(3-hydroxyphenyl)methyl]oxolan-2-one