3986 T3D3931 Thiabendazole Thiabendazole is a fungicide and parasiticide. It is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables; it is also used as a prophylactic treatment for Dutch elm disease. As an antiparasitic, it is able to control roundworms (such as those causing strongyloidiasis), hookworms, and other helminth species which attack wild animals, livestock and humans. 148-79-8 5430 C10H7N3S 201.25 White powder. 300°C 50 mg/L (at 25°C) Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin. The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase. Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. Route of Elimination: It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. Half Life: The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours). The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis. 2013-04-25T07:56:55Z 2026-04-16T22:57:18Z Thiabendazole C07131 45979 DB00730 TMG true N1C2=CC=CC=C2N=C1C1=CSC=N1 C10H7N3S InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13) WJCNZQLZVWNLKY-UHFFFAOYSA-N 201.248 201.036067929 Exogenous Solid 2.47 HMDB14868 CHEMBL625 5237 <p>Lynn E. Applegate, Carl A. Renner, &#8220;Preparation of high purity thiabendazole.&#8221; U.S. Patent US5310923, issued October, 1977.</p> CHEM002892 DTXSID0021337 NS00007958 2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazole