3905 Flusilazole Flusilazole (DPX-H6573) is an organosilicon fungicide invented by DuPont, which is used to control fungal infections on a variety of fruit and vegetable crops. It is moderately toxic to animals and has been shown to produce birth defects and embryotoxicity at high doses. 85509-19-9 73675 C16H15F2N3Si White powder. 48°C Flusilazole has a dose-related inhibition of serum testosterone and estradiol concentrations in rats. This inhibition of testosterone and estradiol biosynthesis may disrupt the hypothalamus–pituitary–testis axis, resulting in overstimulation of the testicular endocrine tissues and increase the risk of Leydig-cell tumours. LD50 (rat, oral) =1110 mg/kg (m) LD50 (rat, dermal) >2000 mg/kg Not listed by IARC. This is a man-made compound that is used as a pesticide. Flusilazole can cause testicular Leydig-cell tumours and bladder tumours in rats and hepatocellular tumours in mouse. An increased gestation length and increased placental weight have been found in the reproductive toxicity studies. Symptoms include weight loss, weakness, lethargy, alopecia and diarrhoea. At higher dose, prostration, salivation, laboured breathing, convulsions, and loss of righting reflex would be expected. Flusilazole can also cause mild erythema at the site of application. 2013-04-25T07:56:51Z 2026-04-06T04:03:56Z C18733 true C[Si](CN1C=NC=N1)(C1=CC=C(F)C=C1)C1=CC=C(F)C=C1 C16H15F2N3Si InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 315.3927 315.100330438 Exogenous Solid 3.7 HMDB39815 CHEMBL1900522 66326 CHEM002811 DTXSID3024235 NS00098479 30.71 89.79 29.397715658524767 4 2 0 2.3191228608522807 0 3 3.55 -4.86 4.33e-03 g/l