3866 Clofentezine Clofentezine is an acaricide used for the residual control of mites. It acts primarily as an ovicide, with some activity on early motile stages. Used on a wide range of crops – apples, pears, stone fruit, nuts, ornamentals, almonds etc. The main toxicological effects seen in studies in rats and dogs were hepatotoxicity and changes to the thyroid, including follicular hyperplasia. Clofentezine does not pose a high toxicity risk to humans. 74115-24-5 73670 C14H8Cl2N4 White powder. Oral (rat) > 5200 mg/kg Dermal (rat) > 2100 mg/kg Inhalation (rat) > 0.89 (mg/l) Not listed by IARC. This is a man-made compound that is used as a pesticide. No adverse health effects attributable to clofentezine were detecte during medical surveillance between 1985 and 2004 in workers at a plant manufacturing clofentezine. The medical examination included an extensive physical examination (including height, body weight, skin, ear, nose and throat, and respiratory, nervous, alimentary, reticulo-endothelial and cardiovascular systems, and locomotion) and specific tests for blood pressure and vision. The examination also included tests for hearing, lung function, urine analysis and blood tests when these were considered appropriate. (Makhteshim Agan Industries Ltd, 2004). However, there is an increase of incidences of thyroid adenomas, adenocarcinomas, thyroid hyperplasia, agglomeration of colloid and thyroid hormones in rats receiving prolonged treatment of high dose of clofentezine. 2013-04-25T07:56:50Z 2026-03-27T00:11:00Z C18576 39315 true ClC1=CC=CC=C1C1=NN=C(N=N1)C1=CC=CC=C1Cl C14H8Cl2N4 InChI=1S/C14H8Cl2N4/c15-11-7-3-1-5-9(11)13-17-19-14(20-18-13)10-6-2-4-8-12(10)16/h1-8H UXADOQPNKNTIHB-UHFFFAOYSA-N 303.146 302.01260169 Exogenous Solid CHEMBL17888 66321 CHEM002772 DTXSID9023881 NS00005836 51.56 103.8588 29.020642375683046 2 4 0 -4.6209100129222485 0 3 3.40 -4.07 2.59e-02 g/l