3830 Sporidesmin Sporidesmin is a mycotoxin found in the spores of the fungus Pithomyces chartarum. It is a potent hepatotoxin and is known to cause pithomycotoxicosis (facial eczema, characterized by photosensitisation) in livestock. (A3095) 1456-55-9 99596 C18H20ClN3O6S2 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Sporidesmin and its reduced (dithiol) form undergo cyclic reduction/autoxidation reactions with glutathione and other thiols, generating toxic superoxide radicals, hydrogen peroxide, and hydroxy radicals. It targets the liver, causing pericholangitis and the occlusion of bile ducts, which leads to the accumulation of bile constitutents in the bloodstream. In livestock, this results in a build up of phylloerythrin, a photodyamic metabolite produced by the microbial degradation of chlorophyll in the rumen. High plasma levels of phylloerythrin cause the animals to become sensitive to sunlight. (A3097, A3098) Not listed by IARC. Sporidesmin is a mycotoxin found in the spores of the fungus Pithomyces chartarum. (A3095) Sporidesmin is a potent hepatotoxin, causing liver damage from pericholangitis and the occlusion of bile ducts, which results in the accumulation of bile constitutents in the bloodstream. This is known to lead to pithomycotoxicosis (facial eczema, characterized by photosensitisation) in livestock. Sporidesmin may also be carcinogenic in humans. (A3095, A3096) Sporidesmin causes diarrhea and lack of appetite. Pithomycotoxicosis is characterized by photosensitisation of the skin. (A3095) Administration of zinc salts can protect against the effects of sporidesmin. Zinc forms a stable mercaptide with sporidesmin, preventing its autoxidation to toxic reactive oxygen species. (A3095) 2010-05-27T19:14:43Z 2026-04-06T12:53:51Z true COC1=C2N(C)C3N4C(=O)C5(C)SSC4(C(O)C3(O)C2=CC(Cl)=C1OC)C(=O)N5C C18H20ClN3O6S2 InChI=1S/C18H20ClN3O6S2/c1-16-14(24)22-13-17(26,12(23)18(22,30-29-16)15(25)21(16)3)7-6-8(19)10(27-4)11(28-5)9(7)20(13)2/h6,12-13,23,26H,1-5H3 QTONANGUNATZOU-UHFFFAOYSA-N 473.951 473.048204474 Exogenous Solid CHEM002740 NS00124810 102.78000000000002 112.73439999999998 45.00020869142949 2 7 2 11.876644139067661 -3.905837756611427 0 5 1.73 -2.06 4.16e+00 g/l