3822 Luteoskyrin Luteoskyrin is a mycotoxin produced by the fungus Penicillium islandicum. It is known to be a storage mold contaminant of rice and has been shown to be hepatotoxic and hepatocarcinogenic. (A3069, A3070) 21884-44-6 30840 C30H22O12 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Luteoskyrin is hepatotoxic. It is thought that this is a result of its metabolic reduction to the semiquinone radical catalyzed by NADPH-dependent cytochrome reductases in the liver, leading to the generation of active oxygen species in redox systems. This causes the induction of lipid peroxidation, hepatocellular membrane damage, and elevation of serum transaminase activities, resultin in liver injuries. Luteoskyrin is also hepatocarcinogenic, possibly a result of its ability to induce DNA fragmentation. It is able to bind to DNA, forming chelate-complexes with nucleic acids and select metal ions. Luteoskyrin inhibits the replication, transcription and repair of DNA, which is at least partially because it inhibits RNA polymerase and ribonuclease H. (A2955, A3042, A3070, A3071, A3072) Luteoskyrin accumulates selectively in the liver, with minor distribution to the serum and kidneys. In the liver it is reduced to its semiquinone radical by NADPH-dependent cytochrome reductases. (A3070,A3071) 145 mg/kg subcutaneously and 221 mg/kg orally in mice. (A3069) 3, not classifiable as to its carcinogenicity to humans. (L135) Luteoskyrin is a mycotoxin produced by the fungus Penicillium islandicum. It is known to be a storage mold contaminant of rice. (A3069) Luteoskyrin is hepatotoxic and hepatocarcinogenic, causing hepatic disorders such as liver cirrhosis and liver tumors. (A3069, A3070) 2010-05-21T14:46:10Z 2026-04-03T17:45:28Z true CC1=CC(O)=C2C(O)=C3C(=O)C4C(O)C5C6C(O)C(C(=O)C7=C(O)C8=C(O)C=C(C)C(O)=C8C(=O)C467)C35C(=O)C2=C1O C30H22O12 InChI=1S/C30H22O12/c1-5-3-7(31)9-11(19(5)33)27(41)29-13-14-24(38)17(29)26(40)16-22(36)10-8(32)4-6(2)20(34)12(10)28(42)30(14,16)18(23(13)37)25(39)15(29)21(9)35/h3-4,13-14,17-18,23-24,31-38H,1-2H3 FAZDYVMEXQHRLI-UHFFFAOYSA-N 574.4885 574.111126168 Exogenous Solid 28613 CHEM002735 DTXSID0020787 NS00026980 230.11999999999995 143.68880000000001 54.87610768349246 0 12 8 5.566740446371182 -4.338395485455224 -2 8 1.74 -2.50 1.84e+00 g/l