3808 Emestrin Emestrin is a mycotoxin produced by fungi of the genus Emericella. It mainly targets the heart, liver and thymus. Its action at the chemokine receptor has lead to its consideration as a possible treatment for autoimmune disorders including rheumatoid arthritis, atherosclerosis, multiple sclerosis, and infectious diseases. (A3040, A3041) 97816-62-1 73555 C27H22N2O10S2 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Emestrin causes degeneration of the mitochondria in both cardiac muscle cells and hepatocytes, leading to necrosis. It is also known to act as an antagonist at the chemokine receptor, reducing the inflammatory effects of autoimmune disorders including rheumatoid arthritis, multiple sclerosis, atherosclerosis. Emestrin may also cause DNA fragmentation. (A3040, A3042) LD50: 13.0 mg/kg (Intraperitoneal, Mouse) (A3041) No indication of carcinogenicity to humans (not listed by IARC). Emestrin is a mycotoxin produced by fungi of the genus Emericella. Its action at the chemokine receptor has lead to its consideration as a possible treatment for autoimmune disorders including rheumatoid arthritis, atherosclerosis, multiple sclerosis, and infectious diseases. Emestrin causes damage to the heart, liver and thymus. It can lead to cardiac failure. (A3041) 2010-05-13T19:36:34Z 2026-04-06T13:19:37Z true COC1=CC=CC2=C1OC1=C(O)C=CC(=C1)C(O)C13SSC4(C(O)C5=COC=CC(OC2=O)C5N4C1=O)C(=O)N3C C27H22N2O10S2 InChI=1S/C27H22N2O10S2/c1-28-24(34)27-22(32)14-11-37-9-8-16-19(14)29(27)25(35)26(28,40-41-27)21(31)12-6-7-15(30)18(10-12)38-20-13(23(33)39-16)4-3-5-17(20)36-2/h3-11,16,19,21-22,30-32H,1-2H3 VASYTSFNISZKEL-UHFFFAOYSA-N 598.601 598.071586314 Exogenous Solid CHEM002722 NS00125896 20,24,32-trihydroxy-16-methoxy-29-methyl-6,10,18-trioxa-26,27-dithia-2,29-diazaheptacyclo[23.2.2.1¹,⁴.1²,²⁵.1¹⁹,²³.0³,⁹.0¹²,¹⁷]dotriaconta-4,7,12(17),13,15,19,21,23(31)-octaene-11,28,30-trione