3798 Fumitremorgin C Fumitremorgin C is produced by Aspergillus fumigatus and Neosartorya fischeri. 118974-02-0 403923 C22H25N3O3 White powder. 259.5 - 260.5°C Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Fumitremorgin C inhibits ATP-binding cassette transporter (ACBG2), also known as breast cancer resistance protein. ACBG2 is known to confer multidrug resistance and also affects the bioavailability of different drugs. Thus fumitremorgin C is often used to sensitize cancer patients to chemotherapeutic drugs. Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2974, A2975, A2976, A3027) No indication of carcinogenicity to humans (not listed by IARC). Fumitremorgin C is a mycotoxin that has been found in the fungus Aspergillus fumigatus. (A3024) Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as 'staggers syndrome'. (A2976) Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors and hyperexcitability. (A2976) To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) 2010-05-10T15:03:52Z 2026-03-31T20:50:41Z true COC1=CC2=C(C=C1)C1=C(N2)C(C=C(C)C)N2C(C1)C(=O)N1CCCC1C2=O C22H25N3O3 InChI=1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3 DBEYVIGIPJSTOR-UHFFFAOYSA-N 379.4522 379.189591681 Exogenous Solid HMDB38642 357779 CHEM002712 DTXSID10328045 NS00011723 7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4(9),5,7-tetraene-14,20-dione