3797 Fumitremorgin B Fumitremorgin B is a mycotoxin produced by Aspergillus fumigatus, Aspergillus caespitosus, Penicillium lanosum and Penicillium piscarium. Fumitremorgin B is isolated from A. fumigatus infected rice and miso Fumitremorgin b belongs to the family of Indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole. 12626-17-4 628311 C27H33N3O5 White powder. 211 - 212°C Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2974, A2975, A2976) No indication of carcinogenicity to humans (not listed by IARC). Fumitremorgin B is a mycotoxin that has been found in the fungus Aspergillus fumigatus. (A3024) Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". Fumitremorgin B is also genotoxic and causes DNA damage. (A2976, A3026) Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors and hyperexcitability. (A2976) To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) 2010-05-10T14:51:52Z 2026-04-06T13:35:08Z true COC1=CC2=C(C=C1)C1=C(C(C=C(C)C)N3C(=O)C4CCCN4C(=O)C3(O)C1O)N2CC=C(C)C C27H33N3O5 InChI=1S/C27H33N3O5/c1-15(2)10-12-28-20-14-17(35-5)8-9-18(20)22-23(28)21(13-16(3)4)30-25(32)19-7-6-11-29(19)26(33)27(30,34)24(22)31/h8-10,13-14,19,21,24,31,34H,6-7,11-12H2,1-5H3 WEIYXEFMCIRZHC-UHFFFAOYSA-N 479.568 479.242021181 Exogenous Solid HMDB30203 545701 CHEM002711 NS00126265 1,2-dihydroxy-7-methoxy-10-(3-methylbut-2-en-1-yl)-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4(9),5,7-tetraene-14,20-dione