3791 Citreoviridin A Citreoviridin A is a metabolite of Penicillium citreo-viride, Penicillium toxicarium, Penicillium ochrosalmoneum and Aspergillus terreus. It is isolated from mouldy rice. Toxin formerly responsible for epidemic-like occurrences of cardiac beriberi in East Asia Citreoviridin A belongs to the family of Pyranones and Derivatives. These are compounds containing a pyran ring which bears a ketone. 25425-12-1 6436023 C23H30O6 White powder. 107 - 111°C Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Citreoviridin inhibits both membrane-bound and soluble mitochondrial ATPases. In particular, it inhibits synaptosomal Na+/K+-ATPase, altering synaptic transmission, and binds to the beta subunit of F1-ATPAse. As a result it has been shown to inhibit mitochondrial energy-linked reactions such as ADP-stimulated respiration, ATP-driven reduction of NAD + by succinate, and ATP-driven NAD transhydrogenase. Mycotoxins are often able to enter the liver and kidney by human organic anion transporters (hOATs) and human organic cation transporters (hOCTs). They can also inhibit uptake of anions and cations by these transporters, interfering with the secretion of endogenous metabolites, drugs, and xenobiotics including themselves. This results in increased cellular accumulation of toxic compounds causing nephro- and hepatotoxicity. (A3002, A3003, A3005, A3006, A3014) LD50: 3.6 mg/kg (Subcutaneous, rat) (A3002) LD50: 7.5 mg/kg (Intraperitoneal, Mouse) (A3002) LD50: 29 mg/kg (Oral, Mouse) (A3002) No indication of carcinogenicity to humans (not listed by IARC). Citreoviridin is a mycotoxin that has been isolated in Peniciilium citreo-viride, P. ochrosalmoneum, and P. pulvullorum. It can be found in contaminated rice grains, as well as corn infested by Eupenicillium ochrosalmoneurn. (A3002) Citreoviridin selectively inhibits motor nerve cells in the medulla oblongata and accumulates in the grey matter and brain stem. This can cause central nervous system depression leading to respiratory and cardiovascular failures and death. (A3002, A3004, A3005) Symptoms of citreoviridin exposure include progressive paralysis, vomiting, convulsions, and gradual respiratory disorder. (A3002) 2010-05-06T14:52:05Z 2026-04-03T05:06:40Z true [H]/C(=C(/[H])\C(\[H])=C(/[H])C1=C(C)C(OC)=CC(=O)O1)/C(/[H])=C(\[H])/C(/C)=C(\[H])C1(C)OC(C)C(C)(O)C1O C23H30O6 InChI=1S/C23H30O6/c1-15(14-22(4)21(25)23(5,26)17(3)29-22)11-9-7-8-10-12-18-16(2)19(27-6)13-20(24)28-18/h7-14,17,21,25-26H,1-6H3/b8-7+,11-9+,12-10+,15-14+ JLSVDPQAIKFBTO-USJRQALFSA-N 402.4807 402.204238692 Exogenous Solid HMDB30868 4525192 CHEM002706 NS00018334 85.22000000000001 118.01279999999998 45.46314193988334 6 5 2 12.600983692839542 -3.662280515270547 0 2 3.89 -4.63 9.36e-03 g/l