3780 Aflatrem Aflatrem is a tremorgenic mycotoxin that has been found in the fungus Aspergillus flavus. Tremorgenic mycotoxins affect central nervous system activity and have been implicated in a number of neurologic diseases of cattle collectively known as "staggers syndromes". (A2974) 70553-75-2 107718 C32H39NO4 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. In addition, aflatrem inhibits presynaptic high-conductance Ca+2 activated maxi-K+ channels in the smooth muscle. (A2974, A2975, A2976, A2993) No indication of carcinogenicity to humans (not listed by IARC). Aflatrem is a tremorgenic mycotoxin that has been found in the fungus Aspergillus flavus. (A2974) Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2974) Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors and hyperexcitability. (A2974) To control severe tremorscaused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744) 2010-05-03T19:08:59Z 2026-04-06T14:00:54Z true CC(C)(C=C)C1=C2C3=C(NC2=CC=C1)C1(C)C(C3)CCC2(O)C3=CC(=O)C4OC3(CCC12C)OC4(C)C C32H39NO4 InChI=1S/C32H39NO4/c1-8-27(2,3)20-10-9-11-21-24(20)19-16-18-12-13-31(35)23-17-22(34)26-28(4,5)37-32(23,36-26)15-14-29(31,6)30(18,7)25(19)33-21/h8-11,17-18,26,33,35H,1,12-16H2,2-7H3 YVDJBQQJIDPRKP-UHFFFAOYSA-N 501.6564 501.287908741 Exogenous Solid 96887 CHEM002695 NS00127058 71.55 144.59510000000003 57.18274768741751 2 4 2 13.617501355950719 -3.4033673277239957 0 7 6.06 -6.93 5.94e-05 g/l