3697 Diisobutyl phthalate DIBP is an odorless plasticizer and has excellent heat and light stability. It is the lowest cost plasticizer for cellulose nitrate. DIBP has lower density and freezing point than DBP (dibutyl phthalate, CAS No.: 84-74-2). It has similar properties as dibutyl phthalate and can be used as a substitute for it. 84-69-5 6782 C16H22O4 Colorless liquid. < 25°C 320 °C 1.038 g/cm3 0.0062 mg/mL at 24°C Oral (L1903) ; inhalation (L1903) ; dermal (L1903) Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) Phthalate esters are first hydrolyzed to their monoester derivative. Once formed, the monoester derivative can be further hydrolyzed in vivo to phthalic acid or conjugated to glucuronide, both of which can then be excreted. The terminal or next-to-last carbon atom in the monoester can also be oxidized to an alcohol, which can be excreted as is or first oxidized to an aldehyde, ketone, or carboxylic acid. The monoester and oxidative metabolites are excreted in the urine and faeces. (A2884) LD50: 15000 mg/kg (Oral, Rat) (T13) LD50: 10 g/kg (Dermal, Guinea pig) (T13) LD50: 3749 mg/kg (Intraperitoneal, Rat) (T13) No indication of carcinogenicity to humans (not listed by IARC). DIBP is used in nitro cellulose plastic, nail polish, explosive material, lacquer manufacturing and also with methyl methacrylate applications. (A726) Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) Phthalate esters are endocrine disruptors and can cause a number of developmental malformations termed 'phthalate syndrome'. (A2883) 2009-12-03T20:31:27Z 2026-03-31T19:17:11Z http://en.wikipedia.org/wiki/diisobutyl_phthalate C15205 894546 O-ACETYLCARNITINE true CC(C)COC(=O)C1=CC=CC=C1C(=O)OCC(C)C C16H22O4 InChI=1S/C16H22O4/c1-11(2)9-19-15(17)13-7-5-6-8-14(13)16(18)20-10-12(3)4/h5-8,11-12H,9-10H2,1-4H3 MGWAVDBGNNKXQV-UHFFFAOYSA-N 278.3435 278.151809192 Exogenous Liquid 4.11 HMDB13835 6524 CHEM002613 DTXSID9022522 NS00010605 1,2-bis(2-methylpropyl) benzene-1,2-dicarboxylate