3660 Ochratoxin C Ochratoxin C is a metabolite of Aspergillus ochraceus Ochratoxin C belongs to the family of Ochratoxins and related substances. These are compounds containing the ochratoxin skeleton, which is structurally characterized by the presence of a 3-phenylpropanoic acid N-linked to a 8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxamide moiety[1]. (Reference: [1] http://www.inchem.org/documents/ehc/ehc/ehc105.htm). 4865-85-4 617474 C22H22ClNO6 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Ochratoxin A, a metabolite of Ochratoxin C, has been shown to be weakly mutagenic, possibly by induction of oxidative DNA damage. The nephrotoxin ochratoxin A (OTA) causes a reduction of glomerular filtration rate (GFR) and of para-aminohippuric acid (PAH) clearance. It is a nephrotoxin which blocks plasma membrane anion conductance in Madin-Darby canine kidney (MDCK) cells. (A2869) It is concluded that ochratoxin C is readily converted to ochratoxin A after both oral and intravenous administration. (A2873) No indication of carcinogenicity to humans (not listed by IARC). Human exposure occurs mainly through consumption of improperly stored food products, particularly contaminated grain and pork products, as well as coffee, wine grapes and dried grapes. (L1939) Ochratoxin exposure has been associated with acute tubular necrosis and Balkan endemic nephropathy. Ochratoxin A has been shown to be nephrotoxic; might delay sexual maturation. (A704) Might cause respiratory irritation. (A704) Care is symptomatic and supportive. (A704) 2009-11-13T22:52:25Z 2026-04-06T10:37:36Z http://en.wikipedia.org/wiki/Ochratoxin true CYP1A2 CYP2D6 (A2876) CCOC(=O)C(CC1=CC=CC=C1)N=C(O)C1=CC(Cl)=C2CC(C)OC(=O)C2=C1O C22H22ClNO6 InChI=1S/C22H22ClNO6/c1-3-29-21(27)17(10-13-7-5-4-6-8-13)24-20(26)15-11-16(23)14-9-12(2)30-22(28)18(14)19(15)25/h4-8,11-12,17,25H,3,9-10H2,1-2H3,(H,24,26) BPZZWRPHVVDAPT-UHFFFAOYSA-N 431.866 431.113565148 Exogenous Solid HMDB29400 536626 CHEM002583 NS00120490 5-chloro-N-(1-ethoxy-1-oxo-3-phenylpropan-2-yl)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboximidic acid