3637 epsilon-Amanitin epsilon-Amanitin is one of a group of at least eight Amatoxins found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) 21705-02-2 57473119 C39H53N9O14S 903.95502 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis, and hence cell metabolism, grind to a halt and the cell dies. (L1774) LD50: 0.3-0.6 mg/kg (Mouse) (T258) 0.1 mg/kg for an adult human. (L1774) No indication of carcinogenicity to humans (not listed by IARC). Amatoxins are a subgroup of at least eight toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (L1774) Amatoxins cause liver damage. They may also affect the kidneys. The most severe effects are toxic hepatitis with centrolobular necrosis and hepatic steatosis, as well as acute tubulointerstitial nephropathy, which altogether induce a severe hepatorenal syndrome. (L1774) Diarrhea and cramps are the first symptoms. (L993) Treatment involves high dose penicillin as well as supportive care in cases of hepatic and renal injury. Cautious attention is given to maintaining hemodynamic stability, although if hepatorenal syndrome has developed the prognosis is guarded at best. (L1774) 2009-08-12T21:34:05Z 2026-04-06T12:33:18Z http://en.wikipedia.org/wiki/Epsilon-Amanitin Amanitin, epsilon- true [H][C@@](C)(O)[C@]([H])(C)[C@]1([H])N=C(O)[C@]2([H])C[C@@]([H])(O)CN2C(=O)[C@]([H])(CC(O)=O)N=C(O)[C@]2([H])CS(=O)C3=C(C[C@@]([H])(N=C1O)C(O)=NCC(O)=N[C@]([H])(C(O)=NCC(O)=N2)[C@@]([H])(C)CC)C1=C(N3)C=C(O)C=C1 C39H53N9O14S InChI=1S/C39H53N9O14S/c1-5-16(2)31-36(59)41-12-28(52)42-26-15-63(62)38-22(21-7-6-19(50)8-23(21)45-38)10-24(33(56)40-13-29(53)46-31)43-37(60)32(17(3)18(4)49)47-35(58)27-9-20(51)14-48(27)39(61)25(11-30(54)55)44-34(26)57/h6-8,16-18,20,24-27,31-32,45,49-51H,5,9-15H2,1-4H3,(H,40,56)(H,41,59)(H,42,52)(H,43,60)(H,44,57)(H,46,53)(H,47,58)(H,54,55)/t16-,17-,18-,20+,24-,25-,26-,27-,31-,32-,63?/m0/s1 OFILNAORONITPV-ZUROAWGWSA-N 903.96 903.343268597 Exogenous Solid 26234941 CHEM002566 NS00124015 2-[(1R,4S,8R,10S,13S,16R,34S)-34-[(2S)-butan-2-yl]-2,8,11,14,22,30,33,36,39-nonahydroxy-13-[(2R,3S)-3-hydroxybutan-2-yl]-5,27-dioxo-27λ⁴-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0⁶,¹⁰.0¹⁸,²⁶.0¹⁹,²⁴]nonatriaconta-2,11,14,18(26),19(24),20,22,29,32,35,38-undecaen-4-yl]acetic acid