3610 Guanidine nitrate Guanidine nitrate is a nitrate of guanidine. It is a high energy fuel used in some gas generator and solid rocket propellant applications. Nitrite is a toxic compound known to cause methemoglobinemia. (L1137, L1627) 506-93-4 10481 CH6N4O3 122.043990 White powder. 214°C Oral (L1137) ; inhalation (L1137) Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137) LD50: 989.6 mg/kg (Oral, Rat) (A676) Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135) It is a high energy fuel used in some gas generator and solid rocket propellant applications. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137) Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137) Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613) 2009-08-05T17:08:35Z 2026-04-05T17:10:10Z http://en.wikipedia.org/wiki/Guanidine_nitrate Guanidine nitrate 3748 true NC(N)=N.O[N+]([O-])=O CH6N4O3 InChI=1S/CH5N3.HNO3/c2*2-1(3)4/h(H5,2,3,4);(H,2,3,4) CNUNWZZSUJPAHX-UHFFFAOYSA-N 122.0833 122.043990078 Exogenous Solid 10049 CHEM002550 DTXSID3027164 NS00078336 guanidine; nitric acid