3546 Fluoroacetic acid Fluoroacetate is highly toxic to mammals and insects and it is used as a pesticide. The more common fluorinated acetic acid, trifluoroacetic acid and its sodium salt are far less toxic. (L1713) 144-49-0 5237 C2H3FO2 78.011710 Odourless colourless crystals. (L138) 35.2°C 165 °C (at 760 mm Hg) 1.37 (at 36 °C) 50 mg/L (at 25 °C) 1.3 mm Hg (at 25 °C) (Estimated) Inhalation (L1685) Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle by combining with coenzyme A to form fluoroacetyl CoA. Fluoroacetyl CoA then reacts with citrate synthase to produce fluorocitrate. A metabolite of fluorocitrate binds very tightly to aconitase, thereby halting the citric acid cycle. This inhibition results in an accumulation of citrate in the blood which deprives cells of energy. (L1713) (A2849) (A2850) No indication of carcinogenicity to humans (not listed by IARC). This is a man-made compound that is used as a pesticide. Fluoroacetic acid is corrosive to the eyes, the skin and the respiratory tract. It may cause effects on the cardiovascular system, central nervous system, kidneys, resulting in impaired functions including cardiac and renal failure. Exposure may result in death. (L1685) (L138) Cough, laboured breathing, nausea, sore throat, vomiting, excessive salivation, numbness and tingling sensation, arrhythmia are observed after fluoroacetic acid inhalation; redness, serious skin burns, pain occur after skin contact; abdominal pain and convulsions in case of ingestion; blurred vision and severe deep burns if eye contact. These symptoms may be delayed. (L1685) 2009-07-30T17:58:52Z 2026-03-31T16:51:32Z http://en.wikipedia.org/wiki/Sodium_fluoroacetate C06108 30775 CPD-121 Fluoroacetic acid 9578 true OC(=O)CF C2H3FO2 InChI=1S/C2H3FO2/c3-1-2(4)5/h1H2,(H,4,5) QEWYKACRFQMRMB-UHFFFAOYSA-N 78.0424 78.011707545 Exogenous Solid CHEMBL509273 10205670 CHEM002516 DTXSID0041981 NS00008445 2-fluoroacetic acid