3512 Ethenyl acetate Polyvinyl acetate is used as a food additive [EAFUS] (EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]). Ethenyl acetate belongs to the family of Carboxylic Acid Esters. These are carboxylic acid derivatives in which the carbo atom from the carbonyl group is atached to an alkyl or oaryl moiety through an oxygen atom (forming an ester group). 108-05-4 7904 C4H6O2 86.036780 -100°C 20 mg/mL at 20°C Oral (L565) ; inhalation (L565) ; dermal (L565) One of the metabolites of vinyl acetate, acetaldehyde, is a known animal carcinogen. Acetaldehyde can form adducts with DNA, causing damage such as cross-links. (L1304, A354) Vinyl acetate may be absorbed following ingestion, inhalation, or dermal exposure, and distributes throughout the body. It is rapidly hydrolyzed by esterases in the blood to acetate and the unstable intermediate, vinyl alcohol. Vinyl alcohol is then rapidly converted to acetaldehyde, which in turn is metabolized to acetate in the liver. This in turn is incorporated into the "2 carbon pool" of normal body metabolism and eventually forms carbon dioxide as the major breakdown product, which is expired. (L1304) LD50: 2.92 g/kg (Oral, Rat) (T55) LC50: 2511 ppm over 4 hours (Inhalation, Rabbit) (T20) 2B, possibly carcinogenic to humans. (L135) Vinyl acetate is used mainly for the production of other industrial chemicals, such as polyvinyl acetate, an important polymer for which it is the precursor. These chemicals are used mainly to make glues for the packaging and building industries. They are also used to make paints, textiles, and paper. Vinyl acetate is also used as a coating in plastic films for food packaging and as a modifier of food starch. (L1302, L1304) Intermediate Inhalation: 0.01 ppm (L134) Vinyl acetate may affect the immune system. It may also be a carcinogen. (L1304) Inhalation of vinyl acetate irritates the eyes, nose, and throat. Skin contact causes irritation and blisters. (L1304) 2009-07-30T17:58:33Z 2016-11-09T01:08:52Z C19309 46916 Vinyl acetate 1463 true CC(=O)OC=C C4H6O2 InChI=1S/C4H6O2/c1-3-6-4(2)5/h3H,1H2,2H3 XTXRWKRVRITETP-UHFFFAOYSA-N 86.0892 86.036779436 Exogenous Liquid 0.73 HMDB31209 CHEMBL1470323 7616 CHEM002499 ethenyl acetate