<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">3251</id>
  <title>T3D3209</title>
  <common-name>Diazenedicarboxamide</common-name>
  <description>Bleaching agent for flour. Diazenedicarboxamide belongs to the family of Azo Compounds. These are derivatives ofA diazene(diimide), HN=NH, wherein both hydrogens are substituted by hydrocarbyl groups, e.g. PhN=NPhA azobenzeneA or diphenyldiazene.</description>
  <cas>123-77-3</cas>
  <pubchem-id>5462814</pubchem-id>
  <chemical-formula>C2H4N4O2</chemical-formula>
  <weight>116.033420</weight>
  <appearance>Pale yellow crystalline (A659).</appearance>
  <melting-point>225°C</melting-point>
  <boiling-point></boiling-point>
  <density nil="true"/>
  <solubility>0.035 mg/mL at 20°C</solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure>Dermal (L1216) ; eye contact (L1216) ; inhalation (L1216) ; oral (L1216)</route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity>Azodicarbonamide prevents the progression of human CD4+ T lymphocytes into the G1 phase of the cell cycle, inhibits their blastogenesis, down-regulates their membrane expression of CD25 and CD69, and decreases their transcription of cytokine genes (A337).</mechanism-of-toxicity>
  <metabolism>Azodicarbonamide is readily converted to biurea, the only breakdown product identified, and it is likely that systemic exposure is principally to this derivative rather than to the parent compound. Biurea is then eliminated rapidly from all tissues with the majority of the elimination via the urine (L1214, A336).</metabolism>
  <toxicity>LD50: &gt;2,000 mg/kg (Dermal, Rabbit) (L1214)</toxicity>
  <lethaldose></lethaldose>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>It is used in food industry as a food additive, a flour bleaching agent and improving agent. The principal use of Azodicarbonamide is in the production of foamed plastics (L1213).</use-source>
  <min-risk-level></min-risk-level>
  <health-effects>Poisoning can cause pulmonary sensitization and dermatitis in people (L1214). </health-effects>
  <symptoms>Symptoms and signs include shortness of breath, chest tightness, wheezing, cough, rhinitis, conjunctivitis, and rash (L1214).</symptoms>
  <treatment>After inhalation exposure, first aid treatment includes fresh air and rest. After skin exposure, remove contaminated clothes, then rinse and wash skin with water and soap. After eye exposure, rinse with plenty of water for several minutes (remove contact lenses if easily possible). After ingestion, rinse mouth, give plenty of water to drink, and rest. In all causes medical attention should be sought. (L1216)</treatment>
  <created-at type="dateTime">2009-07-30T17:56:25Z</created-at>
  <updated-at type="dateTime">2026-05-14T19:59:56Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia></wikipedia>
  <uniprot-id></uniprot-id>
  <kegg-compound-id></kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id>140828</chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id></ctd-id>
  <stitch-id>Azodicarbonamide</stitch-id>
  <drugbank-id>DB16861</drugbank-id>
  <pdb-id></pdb-id>
  <actor-id>3637</actor-id>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>OC(=N)\N=N\C(O)=N</moldb-smiles>
  <moldb-formula>C2H4N4O2</moldb-formula>
  <moldb-inchi>InChI=1S/C2H4N4O2/c3-1(7)5-6-2(4)8/h(H2,3,7)(H2,4,8)/b6-5+</moldb-inchi>
  <moldb-inchikey>XOZUGNYVDXMRKW-AATRIKPKSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">116.0788</moldb-average-mass>
  <moldb-mono-mass type="decimal">116.033425392</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp>-1.7</logp>
  <hmdb-id>HMDB29616</hmdb-id>
  <chembl-id></chembl-id>
  <chemspider-id>4575589</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM002446</chemdb-id>
  <dsstox-id>DTXSID0024553</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id nil="true"/>
  <iupac>(E)-(carbamoylimino)urea</iupac>
  <moldb-polar-surface-area>112.88000000000001</moldb-polar-surface-area>
  <moldb-refractivity>45.3584</moldb-refractivity>
  <moldb-polarizability>9.483747924772825</moldb-polarizability>
  <moldb-rotatable-bond-count>0</moldb-rotatable-bond-count>
  <moldb-acceptor-count>6</moldb-acceptor-count>
  <moldb-donor-count>4</moldb-donor-count>
  <moldb-pka-strongest-acidic>3.0379430618494365</moldb-pka-strongest-acidic>
  <moldb-pka-strongest-basic>1.9307524773009925</moldb-pka-strongest-basic>
  <moldb-physiological-charge>0</moldb-physiological-charge>
  <moldb-number-of-rings>0</moldb-number-of-rings>
  <moldb-alogps-logp>-1.02</moldb-alogps-logp>
  <moldb-alogps-logs>-2.45</moldb-alogps-logs>
  <moldb-alogps-solubility>4.09e-01 g/l</moldb-alogps-solubility>
</compound>
