<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">3140</id>
  <title>T3D3098</title>
  <common-name>Alcuronium</common-name>
  <description>Alcuronium is a type of curare, a plant toxin known for its use as paralyzing arrow poison by South American indigenous people. It can be extracted from a variety of plants, including Strychnos toxifera and Chondrodendron tomentosum. Curares are active only by an injection. They are harmless if taken orally because curare compounds are too large and too highly charged to pass through the lining of the digestive tract to be absorbed into the blood. (L1256)</description>
  <cas>23214-96-2</cas>
  <pubchem-id>5360723</pubchem-id>
  <chemical-formula>C44H50Br2N4O2</chemical-formula>
  <weight>666.8934</weight>
  <appearance>White powder.</appearance>
  <melting-point></melting-point>
  <boiling-point nil="true"/>
  <density nil="true"/>
  <solubility></solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure>Injection (sting/bite) (L1256)</route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity>Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256)</mechanism-of-toxicity>
  <metabolism nil="true"/>
  <toxicity nil="true"/>
  <lethaldose nil="true"/>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>Alcuronium is a type of curare, a plant toxin known for its use as paralyzing arrow poison by South American indigenous people. It can be extracted from a variety of plants, including Strychnos toxifera and Chondrodendron tomentosum. (L1256)</use-source>
  <min-risk-level nil="true"/>
  <health-effects>Curare is a muscle relaxant that can lead to death from asphyxiation, as the respiratory muscles are unable to contract. (L1256)</health-effects>
  <symptoms>Curare is a muscle relaxant and thus causes paraylsis. (L1256)</symptoms>
  <treatment>The antidote for curare poisoning is an acetylcholinesterase inhibitor (anti-cholinesterase), such as physostigmine or neostigmine. (L1256)</treatment>
  <created-at type="dateTime">2009-07-23T18:26:15Z</created-at>
  <updated-at type="dateTime">2026-05-14T19:35:37Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia nil="true"/>
  <uniprot-id nil="true"/>
  <kegg-compound-id></kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id>25520</chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id nil="true"/>
  <stitch-id>Alcuronium </stitch-id>
  <drugbank-id>DB13648</drugbank-id>
  <pdb-id nil="true"/>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>[Br-].[Br-].[H]\C(CO)=C1/C[N+]2(CC=C)CCC34C5=CC=CC=C5N5\C([H])=C6/[C@]7([H])N(\C([H])=C(/[C@@]35[H])[C@@]1([H])C[C@]24[H])C1=CC=CC=C1[C@@]71CC[N+]2(CC=C)C\C(=C(/[H])CO)[C@]6([H])C[C@@]12[H]</moldb-smiles>
  <moldb-formula>C44H50Br2N4O2</moldb-formula>
  <moldb-inchi>InChI=1S/C44H50N4O2.2BrH/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49;;/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2;2*1H/q+2;;/p-2/b29-13-,30-14-,33-25-,34-26-;;/t31-,32-,39-,40-,41-,42-,43+,44?,47?,48?;;/m0../s1</moldb-inchi>
  <moldb-inchikey>BXTUHNWXQLWICJ-FRBQZQGESA-L</moldb-inchikey>
  <moldb-average-mass type="decimal">826.701</moldb-average-mass>
  <moldb-mono-mass type="decimal">824.230052158</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp>-4.3</logp>
  <hmdb-id nil="true"/>
  <chembl-id nil="true"/>
  <chemspider-id>23288959</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM002433</chemdb-id>
  <dsstox-id>DTXSID8048234</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00009463</susdat-id>
  <iupac>(1S,9Z,11S,13S,14R,17S,25Z,27S,28E,30R,33S,35S,37E,38S)-28,37-bis(2-hydroxyethylidene)-14,30-bis(prop-2-en-1-yl)-8,14,24,30-tetraazaundecacyclo[25.5.2.2^{11,14}.1^{1,8}.1^{10,17}.0^{2,7}.0^{13,17}.0^{18,23}.0^{30,33}.0^{24,35}.0^{26,38}]octatriaconta-2(7),3,5,9,18(23),19,21,25-octaene-14,30-diium</iupac>
  <moldb-polar-surface-area>46.94</moldb-polar-surface-area>
  <moldb-refractivity>226.64059999999998</moldb-refractivity>
  <moldb-polarizability>77.42471717254074</moldb-polarizability>
  <moldb-rotatable-bond-count>6</moldb-rotatable-bond-count>
  <moldb-acceptor-count>4</moldb-acceptor-count>
  <moldb-donor-count>2</moldb-donor-count>
  <moldb-pka-strongest-acidic>15.298758537965227</moldb-pka-strongest-acidic>
  <moldb-pka-strongest-basic>1.5213322885445746</moldb-pka-strongest-basic>
  <moldb-physiological-charge>2</moldb-physiological-charge>
  <moldb-number-of-rings>11</moldb-number-of-rings>
  <moldb-alogps-logp>2.46</moldb-alogps-logp>
  <moldb-alogps-logs>-6.11</moldb-alogps-logs>
  <moldb-alogps-solubility>6.40e-04 g/l</moldb-alogps-solubility>
</compound>
