3136 Oleandrin Oleandrin is a plant toxin found in Oleander (Nerium oleander). It causes both gastrointestinal and cardiac effects. (L1253) 465-16-7 261943 C32H48O9 576.71812 White powder. Oral (ingestion) (L1817) ; dermal (L1817) Oleandrin likely exerts its toxic effects by inhibiting Na+,K+-ATPase. (A2831) No indication of carcinogenicity to humans (not listed by IARC). Oleandrin is a plant toxin found in Oleander (Nerium oleander). (L1253) Oleandrin causes both gastrointestinal and cardiac effects. Reactions to poisonings from this plant can also affect the central nervous system, possibly resulting in coma that can lead to death. (L1253) The gastrointestinal effects can consist of nausea and vomiting, excess salivation, abdominal pain, diarrhea, and colic. Cardiac reactions consist of irregular heart rate, and extremities may become pale and cold due to poor or irregular circulation. Reactions to poisonings from this plant can also affect the central nervous system. These symptoms can include drowsiness, tremors or shaking of the muscles, seizures, collapse, and even coma that can lead to death. Oleander sap can cause skin irritations, severe eye inflammation and irritation, and allergy reactions characterized by dermatitis. (L1253) Oleandrin poisoning is treated by induced vomiting, gastric lavage, and/or administration of activated charcoal to prevent further absorption. In severe cases, the antidote Digoxin Immune Fab may be used. (L1254) 2009-07-23T18:26:13Z 2026-05-14T19:26:27Z Oleandrin DB12843 true [H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@H](C[C@]34O)OC(C)=O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)OC1CC(OC)C(O)C(C)O1 C32H48O9 InChI=1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17?,20-,21+,22+,23-,24?,25+,27?,28+,29?,30+,31-,32+/m1/s1 JLPDBLFIVFSOCC-UJQZKUKMSA-N 576.7181 576.329833134 Exogenous Solid 2.95 229992 CHEM002429 DTXSID40861950 NS00004981 (1S,2S,5S,7R,10R,11S,13S,14R,15R)-11-hydroxy-5-{[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-2,15-dimethyl-14-(5-oxo-2,5-dihydrofuran-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl acetate 120.75000000000001 148.45109999999997 63.3856528536424 6 7 2 6.819477159430852 -3.203886689169476 -1 6 2.10 -5.28 2.99e-03 g/l