3134 Grayanotoxin III Grayanotoxins are toxins found in rhododendrons and other plants of the family Ericaceae. It can be found in honey made from their nectar and cause a very rare poisonous reaction called grayanotoxin poisoning, honey intoxication, or rhododendron poisoning. (L1251) 4678-45-9 73051 C20H34O6 370.235540 White powder. Oral (ingestion) (L1817) ; dermal (L1817) Grayanotoxins bind to specific sodium ion channels in cell membranes. The grayanotoxins prevent inactivation, leaving excitable cells depolarized. (L1251) No indication of carcinogenicity to humans (not listed by IARC). Grayanotoxins are toxins found in rhododendrons and other plants of the family Ericaceae. (L1251) Grayanotoxins affect the nervous system but are not usually fatal. (L1251) Initial symptoms include excessive salivation, perspiration, vomiting, dizziness, weakness and paresthesia in the extremities and around the mouth, low blood pressure and sinus bradycardia. In higher doses symptoms can include loss of coordination, severe and progressive muscular weakness, bradycardia (and, paradoxically, ventricular tachycardia), and nodal rhythm or Wolff-Parkinson-White syndrome. (L1251) Medical treatment is not often needed but sometimes atropine therapy, vasopressors and other agents are used to mitigate symptoms. (L1251) 2009-07-23T18:26:12Z 2026-04-06T02:20:07Z Grayanotoxin III true CC1(O)CC23CC(O)C4(O)C(CC(O)C4(C)C)C(C)(O)C2CCC1C3O C20H34O6 InChI=1S/C20H34O6/c1-16(2)13(21)7-12-18(4,25)11-6-5-10-15(23)19(11,9-17(10,3)24)8-14(22)20(12,16)26/h10-15,21-26H,5-9H2,1-4H3 BWMFRQKICHXLSH-UHFFFAOYSA-N 370.4804 370.23553882 Exogenous Solid 9232889 CHEM002428 DTXSID60878540 NS00094763 121.38000000000001 94.9526 40.05917427558426 0 6 6 13.038711053898012 -2.936582011360435 0 4 0.11 -1.49 1.19e+01 g/l