3128 Strychnine Strychnine is a plant toxin most commonly found in the seeds of the Strychnine tree (Strychnos nux-vomica L.). It is used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine causes muscular convulsions and eventually death through asphyxia or sheer exhaustion. (L1230) 57-24-9 441071 C21H22N2O2 334.41158 White powder. 287°C 0.16 mg/mL at 25°C [SEIDELL,A (1941)] Oral (ingestion) (L1817) ; dermal (L1817) Strychnine acts as an antagonist at the inhibitory or strychnine-sensitive glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain. (L1230) LD50: 2350 ug/kg (Oral, Rat) (T14) LD50: 1100 ug/kg (Intraperitoneal, Rat) (T14) LD50: 1200 ug/kg (Subcutaneous, Rat) (T14) LD50: 582 ug/kg (Intravenous, Rat) (T14) No indication of carcinogenicity to humans (not listed by IARC). Strychnine is a plant toxin most commonly found in the seeds of the Strychnine tree (Strychnos nux-vomica L.). It is used as a pesticide, particularly for killing small vertebrates such as birds and rodents. (L1230) Death may result from asphyxia or sheer exhaustion. (L1230) Strychnine causes muscular convulsions of increasing intensity and frequency and eventually death through asphyxia or sheer exhaustion. (L1230) Treatment of strychnine poisoning involves an oral application of an activated charcoal infusion to absorb any poison within the digestive tract that has not yet been absorbed into the blood. Anticonvulsants such as phenobarbital or diazepam are administered to control convulsions, along with muscle relaxants such as dantrolene to combat muscle rigidity. (L1228) 2009-07-23T18:26:10Z 2026-05-14T19:53:53Z http://en.wikipedia.org/wiki/Strychnine C06522 28973 Strychnine DB15954 3106 true O=C1CC2OCC=C3CN4CCC56C4CC3C2C5N1C1=CC=CC=C61 C21H22N2O2 InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 334.4116 334.168127958 Exogenous Solid 0.93 389877 CHEM002423 DTXSID6023600 NS00009135 (1R,11S,18S,20R,21R,22S)-12-oxa-8,17-diazaheptacyclo[15.5.2.0^{1,18}.0^{2,7}.0^{8,22}.0^{11,21}.0^{15,20}]tetracosa-2,4,6,14-tetraen-9-one 32.78 94.50770000000001 35.78897331005339 0 3 0 17.23974507177592 9.27349386578478 1 7 1.68 -2.29 1.72e+00 g/l