3126 Resiniferatoxin Resiniferatoxin (RTX) is a plant toxin and ultrapotent capsaicin analog that occurs in various species of plants, such as resin spurge (Euphorbia resinifera). It evokes a powerful irritant effect followed by desensitization and analgesia. (L1244) 57444-62-9 104826 C37H40O9 628.7081 White powder. Oral (ingestion) (L1817) ; dermal (L1817) Resiniferatoxin activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain). RTX causes a novel ion channel in the plasma membrane of sensory neurons, the transient receptor potential vanilloid 1, to become permeable to cations, most particularly the calcium cation. This evokes a powerful irritant effect followed by desensitization and analgesia. (L1244) No indication of carcinogenicity to humans (not listed by IARC). Resiniferatoxin (RTX) is a plant toxin and ultrapotent capsaicin analog that occurs in various species of plants, such as resin spurge (Euphorbia resinifera). (L1244) Investigated for use/treatment in interstitial cystitis and urinary incontinence. Resiniferatoxin is a neurotoxin that targets afferent sensory neurons involved in nociception. It evokes a powerful irritant effect followed by desensitization and analgesia. (L1244) Resiniferatoxin evokes a powerful irritant effect followed by desensitization and analgesia. (L1244) 2009-07-23T18:26:08Z 2026-05-14T18:21:06Z http://en.wikipedia.org/wiki/Resiniferatoxin C09179 Resiniferatoxin DB06515 true [H][C@]12OC3(CC4=CC=CC=C4)O[C@]1(C[C@@H](C)[C@]1(O3)[C@]3([H])C=C(C)C(=O)[C@@]3(O)CC(COC(=O)CC3=CC(OC)=C(O)C=C3)=C[C@@]21[H])C(C)=C C37H40O9 InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36?,37-/m1/s1 DSDNAKHZNJAGHN-IHCAYWNCSA-N 628.7081 628.267232878 Exogenous Solid CHEMBL448382 94623 CHEM002421 DTXSID00894764 NS00018632 [(1R,2R,6R,10S,11R,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo[11.4.1.0^{1,10}.0^{2,6}.0^{11,15}]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate 120.75000000000003 170.10499999999996 67.2521068318189 9 8 2 9.93540161024193 -3.8507489946897175 0 7 4.40 -5.88 8.20e-04 g/l