3123 (-)-Gossypol (-)-Gossypol is found in fats and oils. (-)-Gossypol is a constituent of Gossypium hirsutum (cotton). (-)-gossypol has been shown to exhibit anti-tumor, anti-cancer and anti-proliferative functions (A7832, A7833, A7834). 90141-22-3 3503 C30H30O8 518.194070 White powder. 178 - 183°C Oral (ingestion) (L1817) ; dermal (L1817) Gossypol may cause apoptosis via the regulation of Bax and Bcl-2 proteins. It is also an inhibitor of calcineurin and protein kinases C, and has been shown to bind calmodulin. (L1239) No indication of carcinogenicity to humans (not listed by IARC). Gossypol is a plant toxin found in the cotton plant (genus Gossypium, family Malvaceae). Among other things, it has been tested as a male oral contraceptive in China. In addition to its contraceptive properties, gossypol has also long been known to possess anti-malarial properties. (L1239) Gossypol may cause low potassium levels and thus causes temporary paralysis. (L1239) Symptoms of gossypol poisoning include fatigue, muscle weakness, and at its most extreme, paralysis. (L1239) 2009-07-23T18:26:07Z 2026-04-14T19:16:03Z C07667 25520 Gossypol DB13044 true CC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(O)=C1O)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C C30H30O8 InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 QBKSWRVVCFFDOT-UHFFFAOYSA-N 518.5544 518.194067936 Exogenous Solid HMDB40723 3383 CHEM002418 DTXSID5023110 23110 7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carbaldehyde